Williams Hematology

The first edition of Williams Hematology (né Hematology) was published in 1972. This, our 9th edition, will represent our continued efforts over nearly one-half century to provide the most current concepts of the pathophysiology and treatment of hematologic diseases. The rate of growth in our understanding of diseases of blood cells and coagulation pathways provides a challenge for editors of a comprehensive textbook of hematology. The sequencing of individual genomes, analysis of the “dark DNA” and noncoding RNAs, advances in knowledge in proteomics, metabolomics, and other “-omics” fields, as applied to hematologic disorders, have accelerated the understanding of the pathogenesis of the diseases of our interest. The rate at which basic knowledge in molecular and cellular biology and immunology has been translated into improved diagnostic and therapeutic methods is equally impressive. Specific molecular targets for therapy in several hematologic disorders have become reality, and it is not hyperbole to state that hematology is the poster child for the rational design of therapeutics applicable to other fields of medicine.