Applied clinical pharmacokinetics

Upon beginning my thirtieth year as a pharmacist, the number of new approaches that continue to be developed for therapeutic drug monitoring impresses me. The second edition of Applied Clinical Pharmacokinetics includes new methods to dose immunosuppressants (2-hour post dose cyclosporine concentrations, area under the curve methods for cyclosporine and tacrolimus), and the elevation of what were new methods of dosing antibiotics to the mainstream (extended interval and area under the curve methods for aminoglycosides, trough-only monitoring for vancomycin). Other additions include more complete coverage of pediatric patients, dosing during hemoperfusion, an overview of methods preceding the initial and dosage adjustment sections, and a dosing strategies section that groups together initial and dosage adjustment techniques into a logical sequence. Of course, relevant sections, examples, problems, and references have been updated as needed for each chapter. However, one thing that remains unchanged is the general organization and philosophy of the book (please see the excerpt from the first edition following this section).